EuroMRD dPCR ALL 2026
EuroMRD dPCR ALL EQA scheme 2026
Task 7: dPCR for MRD quantification in ALL (IG/TR)
The use of dPCR for the quantification of minimal residual disease (MRD) in lymphoid malignancies has seen a marked increase. Within the EuroMRD Consortium, a dPCR quality assessment scheme was set up and utilized for the standardization and establishment of guidelines for dPCR based MRD quantification in acute lymphoblastic leukemia (ALL). IG/TR dPCR is performed on samples based on the same DNA as provided for Task 2 of the EuroMRD ALL EQA scheme. dPCR analysis should be conducted in accordance with the instructions provided by the organizers.
Task 7 consists of IG/TR target detection and sequence analysis in a diagnostic sample and subsequent quantification of MRD in follow-up (FU) samples.
Starting in 2026, this task is issued once per year, during the spring EQA round.
Performance evaluation and report
Certificates of participation in EQA rounds will be distributed after the EuroMRD meeting of the same calendar year.
After release of the certificates, participants can submit an appeal if they feel that a mistake was made in the assessment of their performance. If applicable, certificates will be adapted based on received appeals.
EQA Educational meeting
During the ESLHO week in November, the annual EuroMRD meeting is organized. At this meeting, the results of all EuroMRD EQA schemes are shown (pseudonymized) and discussed with all EuroMRD participants, in small discussion groups as well as during plenary sessions.
Registration and participation fee
The EuroMRD dPCR ALL EQA scheme is only available for participants of the EuroMRD Consortium that are part of the ALL section. The participation fee is € 300. In addition, the EuroMRD annual fee is charged once to every EuroMRD participant.
Organization
The dPCR ALL EQA scheme is organized by ESLHO (EQA Program Coordinator: Prof. Dr. Jacques J.M. van Dongen) in collaboration with the EuroMRD EQA Committee (dPCR ALL scheme lead: Dr. Daniela Drandi). The members of the EuroMRD EQA Committee are participants of the EuroMRD Consortium. The EuroMRD subject-matter experts provide support for:
Pre-round: Case selection, determination of consensus results
Post-round: Data analysis, performance evaluation, reporting
Details on the task division can be found below.
Task division
Name | Organization/Institute | Tasks |
|---|---|---|
Dr. Daniela Drandi | University of Torino, Torino, IT | Lead dPCR ALL scheme; Reference data/consensus results, data analysis, reporting |
Dr. Heiko Trautmann | UKSH, Kiel, DE | Support for results forms, instructions |
Dr. Conny Eckert | Charité – Universitätsmedizin Berlin, Berlin, DE | Reference data/consensus results |
Dr. Jeremy Hancock | Round 1/QA48 (spring): BRI | Case selection/providing DNA |
Prof. Dr. Jacques J. M. van Dongen, Dr. Bart Lubbers, Gonny van Muiswinkel, Carla Annink | ESLHO, Zutphen, NL | General coordination, preparation & distribution of wet cases, final responsibility for the scheme |